Basic Science Investigations
نویسندگان
چکیده
18F-FDG is formed through radiochemical synthesis from cyclotron-produced 18F (K. Breslow, written communication, June 2000). Production of 18F is through proton bombardment of enriched 18O-water. 18F-fluoride is bound to 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-Dmannopyranose (mannose triflate) under conditions of a stereospecific second-order nucleophilic substitution reaction, which produces no-carrier-added 18F-FDG. The 18FFDG is injected intravenously as an isotonic, sterile, pyrogen-free, clear, colorless solution.
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